Le fabricant suédois de médicaments Camurus AB est en pourparlers pour acquérir la société américaine Braeburn Pharmaceuticals Inc, ce qui pourrait renforcer sa position sur le plus grand marché mondial des traitements contre la dépendance aux opioïdes, selon une personne au courant du dossier.
L’opération potentielle, qui fait suite à un accord entre les États-Unis et l’Union européenne visant à plafonner les droits de douane sur les produits pharmaceutiques à 15 %, constituerait la première grande transaction pharmaceutique transfrontalière dans le cadre de ce nouvel accord.
Camurus, connu pour développer des traitements à action prolongée pour les maladies chroniques, y compris la toxicomanie, a un partenariat de longue date avec la société privée Braeburn. En 2014, la société suédoise a signé un accord de licence exclusif accordant à l’entreprise américaine les droits de commercialisation de la buprénorphine injectable à action prolongée de Camurus, vendue sous le nom de Brixadi aux États-Unis et de Buvidal à l’étranger. Camurus a reçu 20 millions de dollars d’avance et pouvait prétendre à 151 millions de dollars de paiements d’étape liés au développement et aux ventes.
Ce pari a porté ses fruits alors que les États-Unis sont aux prises avec une épidémie d’opioïdes en pleine expansion. La Food and Drug Administration a approuvé Brixadi en 2023, et Braeburn l’a lancé en septembre. Disponible en doses hebdomadaires et mensuelles, plus pratiques que les pilules quotidiennes, le médicament a conquis environ 25 % du marché américain de la buprénorphine à action prolongée à la fin de l’année 2024. Il a généré 212 millions de couronnes suédoises (19 millions de dollars) de redevances pour Camurus l’année dernière.
Une acquisition donnerait à Camurus le contrôle direct des ventes de Brixadi aux États-Unis, où la crise des opioïdes fait environ 80 000 victimes par an, la plupart liées à des surdoses de fentanyl.
Le vaste réseau de distribution de Braeburn à travers Medicaid, Medicare, les programmes fédéraux et les assureurs privés a favorisé une adoption rapide. Les dirigeants de Camurus estiment le potentiel inexploité du marché américain de Brixadi à plus d’un milliard de dollars, citant l’appui solide des médecins, des patients et des payeurs. La performance de la première année du médicament a surpassé les lancements précédents dans la catégorie, le positionnant comme un rival de premier plan pour les thérapies quotidiennes.
Selon Hagman Global Strategies, un groupe de réflexion basé à Londres, le marché américain du traitement des opioïdes devrait se développer à mesure que les initiatives fédérales améliorent l’accès aux médicaments qui réduisent l’état de manque et le sevrage.
Les négociations se déroulent dans le contexte d’un pacte commercial historique entre les États-Unis et l’Union européenne, qui a fixé un plafond tarifaire de 15 % pour la plupart des importations, y compris les produits pharmaceutiques – une bouée de sauvetage pour le secteur européen des médicaments, dont les exportations sont considérables. L’année dernière, l’UE a exporté pour près de 120 milliards d’euros (130 milliards de dollars) de médicaments vers les États-Unis, ce qui représente 38,2 % de ses exportations de produits pharmaceutiques hors UE et fait des produits pharmaceutiques la première catégorie d’exportation de l’Union vers l’Amérique.
Bien que la taille et les conditions de l’accord potentiel n’aient pas été divulguées, il met en évidence la manière dont l’allégement tarifaire stimule déjà les transactions dans un secteur longtemps méfiant à l’égard des barrières commerciales.
Selon Hagman Global Strategies, les entreprises pharmaceutiques européennes, qui ont exporté pour 500 milliards de dollars l’année dernière, voient les États-Unis comme un moteur de croissance, à condition que les coûts transfrontaliers ne grimpent pas en flèche.
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